Overview

Lymphoma is a type of blood cancer that affects the lymphatic system.

Lymphoma includes a diverse group of cancers originating from the abnormal clonal expansion of lymphocytes.
NSCLC It accounts for about 5% of all malignant cancers worldwide.
SCLC The overall survival rate for lymphoma patients is estimated at approximately 72%.
Lymphoma treatment is tailored to the specific type, stage, and presence of symptoms, and may include chemotherapy, radiotherapy, or targeted therapies.

Lymphoma is broadly classified into two main types - Hodgkin lymphoma and non-Hodgkin lymphoma, both of which originate in the lymphocytes, a type of white blood cell.

G2M lymphoma cancer panel includes key features
Comprehensive Coverage: Targets key genes implicated in Hodgkin and non-Hodgkin lymphomas.
Diagnostic, Prognostic & Therapeutic Insight: Identifies mutations that inform diagnosis, predict outcomes, and support treatment decisions.
High Sensitivity: Detects low-frequency somatic variants for accurate disease profiling.
DNA & RNA Analysis: Enables detection of both gene mutations and fusion transcripts in a single assay.
Optimized for Clinical Use: Designed to support personalized medicine and evidence-based care in lymphoid malignancies.

Panel Performance

Features	Performance
Coverage uniformity (0.2X)	>99%
Reproducibility (%)	96.3
Sensitivity (%)	97
On Target Ratio (%)	75-85

Features

Performance

Coverage uniformity (0.2X)

>99%

Reproducibility (%)

96.3

Sensitivity (%)

On Target Ratio (%)

75-85

Panel Specifications

Number of Genes:	153 genes including DNA fusion
Gene count/family:	~75
Target Size:	0.62 Mb
Covered Regions:	Whole Coding Sequence, hotspots
Mutation Types:	SNV / InDels / CNVs/ DNA fusions
Sample Type:	Blood
Platform Compatibility:	Illumina, MGI, Thermo Fisher, Element Biosciences

Ordering Information

Commercial Name	Cat No.	Pack Size	Platform
Lymphoma NGS Test Kit	G710018-1	24 T	Illumina
	G710018-2	96 T	Illumina
	G710018-3	96 T – EZY	Illumina – EZY
Lymphoma NGS Test Kit	G710018-4	24 T	MGI
	G710018-5	96 T	MGI
	G710018-6	96 T – EZY	MGI – EZY
Lymphoma NGS Test Kit	G710018-7	24 T	Aviti
	G710018-8	96 T	Aviti
	G710018-9	96 T – EZY	Aviti – EZY
Lymphoma NGS Test Kit	G710018-10	24 T	Thermo
	G710018-11	96 T	Thermo
	G710018-12	96 T – EZY	Thermo – EZY

Data Analysis and Reporting

Balanced Coverage of Critical Genes Reflects Robust Workflow:

Uniform Gene Coverage Across Lymphoma Samples:

Coverage analysis of key lymphoma associated genes (ALK, BRAF, ATM, and JAK3) demonstrates strong concordance between mean depth and median coverage, indicating minimal bias and uniform sequencing across target regions. This convergence reflects a robust and reliable assay validated across multiple lymphoma specimens.

Exceptional On-Target Performance Across Lymphoma Samples

On-target ratio across lymphoma patient samples:

All patient samples achieved more than 80% on-target alignment, reflecting the panel’s exceptional design precision, optimized assay performance, and highly efficient target capture ensuring reliable, high-quality sequencing efficiency.

Library Quality Assessment for Lymphoma NGS Panel

Bioanalyzer profile of the targeted sequencing library derived from the Seraseq Lymphoma DNA Mutation Mix. The validated workflow demonstrates consistent library size (~350 bp) and concentration (20–40 nM), indicative of robust preparation for NGS analysis.

Mutation Landscape of Top Lymphoma Genes:

Critical Gene Mutation Patterns in Lymphoma:

The Oncoplot shows the somatic mutation landscape of the top 18 lymphoma associated genes. Missense variants (blue) dominate, while multi-hit events (green) indicate multiple mutation types within the same gene. The right panel shows mutation frequency per gene.

Gene-Wise VAF Patterns Reveal Mutation Spectrum in Lymphoma:

Comparative VAF Profiles Across High Priority Genes:

Variant Allele Frequency (VAF) distribution across the top 18 lymphoma associated genes. Boxplots illustrate variability in VAF for each gene, with ALK, TP53, and WNK1 showing the highest ranges, indicating heterogeneity in mutation burden across samples.

Somatic Mutation Mapping in ALK and ATM Genes Highlights Hotspots Across Functional Domains:

Lollipop Visualization of Mutation Hotspots in ALK and ATM:

The plots showing somatic mutation distribution in (A) ALK (mutation rate: 33.33%) and (B) ATM (mutation rate: 42.86%) genes. Missense mutations (green), frameshift insertions (purple), and frameshift deletions (orange) are mapped across functional domains.

Resources

Download useful documents and technical information for the lymphoma.

Product Brochure

IFU (Instructions for Use)

Report File

Since its inception in 2016, Genes2me has been constantly striving towards setting a benchmark in the diagnostics space by introducing premium quality (Made in India) diagnostic kits which are CE-IVD, ISO-13485:2016, and ISO 9001:2015 certified, assuring our clients of unparalleled quality and compliance with international standards.

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