Overview

The EGFR-Q Real-Time PCR Kit from Genes2Me is an advanced in vitro diagnostic solution for the qualitative detection of EGFR somatic mutations in genomic DNA extracted from clinical samples, including fresh tissue and FFPE (formalin-fixed paraffin-embedded) tissue. Designed for use by trained laboratory professionals, this kit delivers high precision, rapid performance, and reliable results to enable confident, personalized treatment decisions in non-small cell lung cancer (NSCLC).

Why is EGFR Testing Critical?- Mutations in the Epidermal Growth Factor Receptor (EGFR) are strongly implicated in the development of non-small cell lung cancer (NSCLC), driving tumor progression, promoting angiogenesis, and contributing to resistance to apoptosis in lung malignancies. Lung cancer remains the leading cause of cancer-related deaths worldwide, with NSCLC accounting for 80% of cases.

Clinical studies have shown that the effectiveness of EGFR tyrosine kinase inhibitors (TKIs) is directly linked to EGFR mutation status. By identifying mutations in exons 18–21 of the EGFR gene - particularly 19del (45% prevalence) and L858R (40 - 45% prevalence)- this kit empowers clinicians to select the right therapy and improve patient survival.

Key features & highlights

Comprehensive Mutation Coverage

Detects clinically important EGFR mutations including L858R, T790M, G719X, Exon 19 deletions (19del), L861Q, Exon 20 insertions (3Ins20), and S768I, delivering a complete mutation profile to guide targeted therapy decisions.

High Sensitivity & Specificity

Capable of detecting mutations at 0.25–0.5% allele frequency, ensuring reliable results even from challenging FFPE samples.

Built-in Internal Control

Continuously monitors sample quality, reagent integrity, and assay workflow to minimize false-negative results.

Fast & Accurate Turnaround

Optimized real-time PCR workflow provides precise mutation results within hours, supporting timely clinical decision-making.

Robust Contamination Control

Features UDG enzyme technology to prevent carryover contamination, ensuring assay reliability.

Broad Platform Compatibilit

Validated with leading PCR systems including QuantStudio™ 5, Bio-Rad CFX96, Roche LightCycler® 480, and Genes2Me RapiCycler 96.

Applications

Clinical Significance: Accurately detects EGFR mutations in NSCLC patients, enabling precision oncology and personalized treatment decisions.
Insights into therapeutics: Supports clinicians in prescribing EGFR-TKIs such as gefitinib, erlotinib, and osimertinib, helping ensure patients receive the most effective targeted therapy.
Diagnostic Utility: Serves as a powerful diagnostic tool that bridges advanced molecular testing with real-world clinical needs, delivering accuracy, efficiency, and confidence in lung cancer management.

Commercial Name	Cat No.	Pack Size
EGFR-Q Real-Time PCR Kit	G2M708121	25 T

Commercial Name

Cat No.

Pack Size

EGFR-Q Real-Time PCR Kit

G2M708121

25 T

Since its inception in 2016, Genes2me has been constantly striving towards setting a benchmark in the diagnostics space by introducing premium quality (Made in India) diagnostic kits which are CE-IVD, ISO-13485:2016, and ISO 9001:2015 certified, assuring our clients of unparalleled quality and compliance with international standards.

Overview