Overview

The FLT3-Q Real-Time PCR Kit from Genes2Me is an advanced in vitro diagnostic solution designed for the detection of internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations in the FLT3 gene. The FLT3 gene (FMS-like Tyrosine Kinase 3) plays a key role in regulating blood cell development. Mutations in FLT3 can lead to uncontrolled production of immature white blood cells and are commonly associated with certain types of leukemia, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). These mutations, present in 20–30% of acute myeloid leukemia (AML) patients, are among the most critical genetic abnormalities influencing disease progression, treatment selection, and prognosis.

Why does FLT3 testing matter? -The FLT3 gene encodes a receptor Tyrosine kinase that regulates cell survival, proliferation, and differentiation. Mutations such as ITD and TKD (D835Y) disrupt this pathway, leading to uncontrolled leukemic cell growth. Identifying FLT3 mutations is crucial for risk stratification in AML, as patients with these mutations often experience aggressive disease but may respond well to FLT3-targeted therapies. Timely and precise mutation detection enables oncologists to select personalized treatment strategies and improve patient outcomes.