The AML1 Fusion Real-Time PCR Test Kit is an advanced in vitro diagnostic solution developed for the detection of TEL-AML1 fusion genes in clinical samples. Leveraging highly sensitive and precise Real-Time PCR technology, this assay delivers fast, accurate, and reproducible results. It plays a vital role in the early diagnosis and prognosis of Acute Lymphoblastic Leukemia (ALL), making it particularly significant in pediatric oncology where timely intervention can greatly improve patient outcomes.
The TEL-AML1 fusion gene results from a chromosomal translocation t(12;21)(p13;q22), which is one of the most frequently observed genetic abnormalities in childhood B-lineage ALL. Identifying this fusion gene not only confirms the diagnosis but also provides valuable prognostic information, helping clinicians tailor treatment strategies to individual patients. By enabling faster, evidence-based clinical decisions, the AML1 Fusion RT-PCR Kit supports improved disease management and better long-term results for patients.
Uses custom primers and fluorescent probes (FAM for TEL-AML1 and HEX for the internal control) to ensure precise detection, with reliable results demonstrated by detection of TEL-AML1 fusion gene with Ct ≤ 35.
RNase P internal control validates sample quality and workflow accuracy, minimizing false negatives and guaranteeing dependable outcomes.
Enables simultaneous detection of multiple targets in a single reaction, enhancing workflow efficiency, conserving reagents, and supporting rapid turnaround.
Optimized for major real-time PCR systems including QuantStudio™ 5, Bio-Rad CFX96, Roche LightCycler® 480, and RapiCycler 96, ensuring seamless integration into diverse laboratory setups.
Designed to deliver timely, consistent, and clinically actionable data to support critical decision-making in leukemia diagnostics.
Features optimized reagents and a 12-month stability profile, ensuring consistent performance and reliable outcomes across varying clinical laboratory conditions.
The leukemic fusion protein AML1-ETO occurs frequently in human acute myeloid leukemia (AML) AML1 fusion Real Time PCR Kit is an in vitro diagnostic test for the qualitative detection of fusion of AML1 & ETO genes in clinical samples.
Fold 80 values for blood samples ranged from 1.23–1.35, showing highly uniform coverage with minimal sequencing bias supporting accurate and dependable variant detection.
Coverage patterns for key cancer genes (BRCA1, PTEN, MSH2, MSH6, RET) show strong consistency, with mean (solid) and median (dashed) values closely aligned.
Download useful documents and technical information of RT PCR AML1 Fusion.
| Commercial Name | Cat No. | Pack Size |
|---|---|---|
| AML1 Fusion Real-Time PCR Test Kit | G2M802921 | 50 T |
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