HPV infection is typically asymptomatic. Low-risk strains of HPV can lead to plantar, common, or genital warts, and focal respiratory papillomatosis. In contrast, high-risk strains are linked to cervical intraepithelial neoplasia (CIN) and various cancers, including cervical, vaginal, vulvar, anal, penile, and oropharyngeal carcinomas. Persistent, high-risk HPV infection is estimated to cause 90% of cervical and anal cancers, 70% of vulvar and vaginal cancers, 60% of penile cancers, and 70% of oropharyngeal cancers. HPV infects various human cells, including skin and epithelial mucosal cells. While some HPV infections are asymptomatic, others can be highly pathogenic. Transmission typically occurs through skin-to-skin or skin-to-mucosal contact, with over 80% of sexually active adults expected to be exposed to HPV at some point in their lives.
G2M provides robust, accurate, and extensively validated kits for detecting HPV infection across all HPV genotypes, including low, medium, and high-risk types. These CE-IVD approved RT-PCR IVD kits offer high sensitivity and specificity, ensuring precise identification of HPV viral infections. They are also highly compatible with the commonly available 4-plex Real-Time PCR instruments.
The HPV-Q Real-Time PCR kit is an in vitro multiplex diagnostic tool designed for HPV identification using E6/E7 gene-specific targets for 14 high-risk genotypes. This kit utilizes specific primers and fluorescent-labeled probes for precise detection. This kit enables the qualitative screening of 14 high-risk genotypes, including distinct identification of HPV 16 and HPV 18, as well as 12 other pooled high-risk HPV genotypes: HPV 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68. The detection process utilizes separate dyes: HPV 16 is labeled with HEX, HPV 18 with ROX, and the 12 pooled high-risk HPV genotypes with FAM. Additionally, the endogenous internal control RNAseP is labeled with Cy5.
The HPV-Q Comprehensive Real-Time PCR kit, on the other hand, is an in vitro diagnostic test for the detection of 28 HPV genotypes, including both high-risk and low- medium risk HPV genotypes, in DNA extracted from clinical samples. This kit allows differential identification of HPV 16 and HPV 18 genotypes, as well as the qualitative detection of 12 high-risk genotypes (HPV 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68) and 14 Medium-Low risk genotypes (HPV 6, 11, 83, 54, 26, 81, 61, 44, 40, 43, 42, 82, 53 and 73).
