{"id":1008,"date":"2026-07-10T11:30:48","date_gmt":"2026-07-10T11:30:48","guid":{"rendered":"https:\/\/genes2me.com\/blog\/?p=1008"},"modified":"2026-07-13T05:41:17","modified_gmt":"2026-07-13T05:41:17","slug":"pancan-cancer-genomic-profiling-assay","status":"publish","type":"post","link":"https:\/\/genes2me.com\/blog\/2026\/07\/10\/pancan-cancer-genomic-profiling-assay\/","title":{"rendered":"One Test. Every Biomarker. Every Solid Tumor PanCan CGP Assay"},"content":{"rendered":"\n
\"\"<\/figure>\n\n\n\n

Cancer is no longer defined solely by its tissue of origin\u2014it is driven by a complex network of genomic alterations that determine disease progression, therapeutic response, and clinical outcomes. As precision oncology continues to evolve, sequential single-gene testing is rapidly becoming insufficient for modern cancer care. Clinicians today require a comprehensive molecular portrait that captures actionable variants, predictive biomarkers, and resistance mechanisms in a single workflow. The Genes2Me PanCan Cancer Genomic Profiling (CGP) Assay<\/a> <\/strong>has been developed to meet this need, offering a hybrid capture-based Next-Generation Sequencing<\/a> (NGS) solution that interrogates 774 clinically relevant genes<\/strong>, multiple biomarker classes, and clinically actionable genomic signatures in one assay. Designed according to internationally accepted ACMG, AMP, NCCN, and ASCO guidelines, the assay enables comprehensive genomic profiling across a wide spectrum of solid tumors while minimizing tissue consumption and reducing turnaround time.<\/p>\n\n\n\n

One Assay Covering the Entire Molecular Landscape of Solid Tumors<\/h2>\n\n\n\n

Unlike conventional disease-specific panels, the PanCan CGP Assay follows a tumor-agnostic approach<\/strong>, enabling comprehensive profiling of multiple solid malignancies\u2014including lung, breast, colorectal, ovarian, pancreatic, prostate, gastric, thyroid, liver, bladder, cervical cancers, gliomas, melanoma, and several rare tumors\u2014using a single standardized workflow. The assay simultaneously detects Single Nucleotide Variants (SNVs), Insertions and Deletions (InDels), Copy Number Variations (CNVs), Microsatellite Instability (MSI), Tumor Mutational Burden (TMB), Homologous Recombination Deficiency (HRD) Score<\/strong>, along with clinically significant biomarkers such as MET Exon 14 Skipping, EGFR Exon 2\u20137 Skipping, ERBB2 (HER2)<\/strong> amplification, PD-L1 DNA amplification, 1p\/1Gq co-deletion, and TERT promoter alterations<\/strong>. By consolidating this extensive biomarker repertoire into a single assay, laboratories can eliminate multiple sequential tests, conserve precious biopsy tissue, and deliver faster, clinically actionable insights for precision treatment selection.<\/p>\n\n\n\n

Comprehensive DNA and RNA Fusion Detection with Tissue and Liquid Biopsy Support<\/h2>\n\n\n\n

Gene fusions represent some of the most actionable biomarkers in oncology, yet their accurate detection often requires complementary analytical approaches. The Genes2Me PanCan CGP Assay integrates both DNA- and RNA-based fusion analysis<\/strong>, combining structural variant detection at the genomic level with confirmation of expressed fusion transcripts. This dual-modality strategy significantly improves the detection of clinically relevant rearrangements while reducing the likelihood of missed fusion events. The assay supports analysis of 105 RNA fusion targets <\/strong>alongside DNA alterations, providing a truly comprehensive molecular assessment within a single workflow. Furthermore, the assay is optimized for both FFPE\/fresh tissue <\/strong>and circulating tumor DNA (ctDNA)<\/a> <\/strong>applications. Standard tissue samples require approximately 4 GB of sequencing data <\/strong>to achieve robust variant detection, whereas the PanCan Liquid Biopsy<\/a> <\/strong>workflow utilizes approximately 40 GB of sequencing data <\/strong>with ultra-deep coverage to enable highly sensitive detection of low-frequency ctDNA variants present in plasma. This ten-fold increase in sequencing depth ensures exceptional analytical sensitivity for liquid biopsy, making the platform equally powerful for tissue-based diagnostics and minimally invasive disease monitoring.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

A Complete End-to-End Precision Oncology Solution<\/h2>\n\n\n\n

Comprehensive genomic profiling extends far beyond sequencing\u2014it requires an integrated ecosystem capable of transforming raw sequencing data into clinically meaningful insights. The Genes2Me PanCan CGP workflow combines hybrid capture-based enrichment, EZY Autoprep-enabled automated liquid<\/a> <\/strong>handling <\/strong>for standardized library preparation, precise reagent dispensing, controlled sample processing, and reduced hands-on variability, along with assay compatibility across major sequencing platforms including Illumina, MGI, Thermo Fisher Scientific, and Element Biosciences<\/strong>, and automated interpretation through the CliSeq Interpreter <\/strong>bioinformatics platform. Backed by robust analytical performance, including >GG% coverage uniformity, G7% reproducibility, 78\u2013G0% on-target ratio, and G8.G%<\/strong> sensitivity at 1% Variant Allele Frequency (VAF)<\/strong>, the assay delivers reliable, reproducible, and clinically actionable genomic information. By integrating broad genomic coverage, DNA and RNA fusion detection, comprehensive biomarker analysis, automation-supported consistency in pre-sequencing library preparation<\/strong>, and validated tissue and liquid biopsy workflows into a single solution, the Genes2Me PanCan CGP Assay empowers laboratories and clinicians to unlock the full potential of precision oncology\u2014because the future of cancer diagnostics lies not in asking one question at a time, but in obtaining every answer from a single test.<\/p>\n","protected":false},"excerpt":{"rendered":"

Cancer is no longer defined solely by its tissue of origin\u2014it is driven by a complex network of genomic alterations that determine disease progression, therapeutic…<\/p>\n","protected":false},"author":1,"featured_media":1010,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[215,214],"tags":[482,473,481,483],"yoast_head":"\nPanCan Cancer Genomic Profiling Assay | Genes2Me<\/title>\n<meta name=\"description\" content=\"PanCan Cancer Genomic Profiling Assay by Genes2Me analyzes 774 genes, DNA\/RNA fusions, MSI, TMB, HRD, and ctDNA for precision oncology in solid tumors.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/genes2me.com\/blog\/2026\/07\/10\/pancan-cancer-genomic-profiling-assay\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PanCan Cancer Genomic Profiling Assay | Genes2Me\" \/>\n<meta property=\"og:description\" content=\"PanCan Cancer Genomic Profiling Assay by Genes2Me analyzes 774 genes, DNA\/RNA fusions, MSI, TMB, HRD, and ctDNA for precision oncology in solid tumors.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/genes2me.com\/blog\/2026\/07\/10\/pancan-cancer-genomic-profiling-assay\/\" \/>\n<meta property=\"og:site_name\" content=\"Genes2Me Blog - 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