Early Screening, Effective Diagnosis
Maternal Serum Screening Tests are the initial stage tests for a pregnant mother. These are screening tests to check for any abnormality that may arise during the pregnancy. If a high risk is reported for any disorder, the pregnant mother can opt for non invasive or invasive procedure to confirm the results.
It is a test that combines maternal blood screening with an ultrasound analysis of the fetus,
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to identify risk for specific chromosomal abnormalities. It measures the following two levels in the maternal serum
It detects for specific chromosomal abnormalities like:
• Trisomy - 21 (Down Syndrome)
• Trisomy - 18 (Edward Syndrome)
It is ideally carried between the 11th to 13th week of pregnancy.
It is an investigation performed during pregnancy in the second trimester
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to classify a patient as either high-risk or low-risk for chromosomal abnormalities (and neural tube defects).
• Alpha - Fetoprotein (AFP)
• Human Chorionic Gonadotropin (hCG)
• Unconjugated Estriol (UE3)
It detects for specific chromosomal abnormalities like:
• Trisomy - 21 (Down Syndrome)
• Trisomy - 18 (Edward Syndrome)
• Open Neural Tube Defects
It is ideally carried out between the 15th-20th weeks of pregnancy.
Similar to the triple screen, the quadruple marker test provides information about whether there is an increased risk for certain birth defects in the baby.
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It measures the following four levels in the maternal serum:
• Alpha - Fetoprotein (AFP)
• Human Chorionic Gonadotropin (hCG)
• Unconjugated Estriol (UE3)
• Inhibin-A
• Trisomy - 21 (Down Syndrome)
• Trisomy - 18 (Edward Syndrome)
• Open Neural Tube Defects
It is ideally carried out between the 15th-20th weeks of pregnancy.
| FEATURES | Double Marker Test | Triple Marker Test | Quadruple Marker Test |
| Ideal Period for screening | 11th to 13th week of pregnancy | 15th to 20th week of pregnancy. | 15th to 20th week of pregnancy. |
| Parameters | Beta HCG, PAPP-A | Beta HCG, AFP, Unconjugated Estriol | Beta HCG, AFP, Unconjugated Estriol, Inhibin-A |
| Screens For | Trisomy - 21 and Trisomy - 18 | Trisomy - 21, Trisomy - 18 and Open Neural Tube Defects | Trisomy - 21, Trisomy - 18 and Open Neural Tube Defects |
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